Liquid chromatography-tandem mass spectrometry for pharmacokinetics evaluation of AZD5305, a selective PARP1 inhibitor, in mice

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors that are effective against ovarian and breast cancers with breast cancer susceptibility gene (BRCA) mutations have undesirable side effects, such as hematological toxicity. AZD5305, a selective PARP1 inhibitor currently in Phase 1/2 clinical tr...

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Bibliographic Details

Published in:	Journal of Analytical Science and Technology
Main Authors:	Gi Ju Lee, Jin Woo Kim, Hae-In Choi, Jin Young Choi, Kwan Hyung Cho, Tae-Sung Koo
Format:	Article
Language:	English
Published:	SpringerOpen 2023-08-01
Subjects:	AZD5305 Poly (ADP-ribose) polymerase inhibitor Liquid chromatography-tandem mass spectrometry Pharmacokinetics
Online Access:	https://doi.org/10.1186/s40543-023-00400-6