The mechanism of COL4A2‐activated FAK‒PI3K‒AKT promotion of osteogenic differentiation in decellularized extracellular matrix

Abstract Previously, we determined that type IV collagen A2 (COL4A2) might be important in the new bone formation of decellularized extracellular matrices (dECMs), but the exact mechanism was unknown. In the present study, we aimed to clarify whether and how COL4A2 positively affects dECM osteogenic...

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Published in:	View
Main Authors:	Ziran Zheng, Changyun Fang, Yuanxin Sun, Mianfeng Yao, Tianru Yang, Jiajun Huang, Dan Wang, Fei Xu
Format:	Article
Language:	English
Published:	Wiley 2025-10-01
Subjects:	COL4A2 decellularized extracellular matrix FAK‒PI3K‒AKT pathway integrin receptor osteogenic differentiation
Online Access:	https://doi.org/10.1002/VIW.20250038