Integrated transcriptomics identifies ER stress–associated apoptosis in post-resuscitation AKI and supports early Dl-3-n-butylphthalide–associated renoprotection in a porcine TCA model

BackgroundDl-3-n-butylphthalide (NBP) is a small-molecule compound derived from celery seeds with anti-inflammatory, antioxidant, and anti-apoptotic properties. Although NBP has shown protective effects in various kidney diseases, its role in traumatic cardiac arrest (TCA)-induced acute kidney injur...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Kechun Zhou, Wang Du, Yi Chen, Yufeng Hu, Pin Lan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2026-06-01
Subjects:	acute kidney injury apoptosis dl-3-n-butylphthalide endoplasmic reticulum stress traumatic cardiac arrest
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1841271/full