Oxidative stress and inflammation cause auditory system damage via glial cell activation and dysregulated expression of gap junction proteins in an experimental model of styrene-induced oto/neurotoxicity

Abstract Background Redox imbalance and inflammation have been proposed as the principal mechanisms of damage in the auditory system, resulting in functional alterations and hearing loss. Microglia and astrocytes play a crucial role in mediating oxidative/inflammatory injury in the central nervous s...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Fabiola Paciello, Anna Pisani, Rolando Rolesi, Raffaele Montuoro, Veronica Mohamed-Hizam, Giammarco Boni, Cristian Ripoli, Jacopo Galli, Renata Sisto, Anna Rita Fetoni, Claudio Grassi
Format:	Article
Language:	English
Published:	BMC 2024-01-01
Subjects:	ROS Pro-inflammatory cytokines Macrophages Microglia morphology Astrogliosis Gap junctions
Online Access:	https://doi.org/10.1186/s12974-023-02996-3