Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants

A new delivery method via polymeric implants was used for continuous exposure to PCBs. Female Sprague-Dawley rats received subcutaneous polymeric implants containing PCB126 (0.15% load), PCB153 (5% load), or both, for up to 45 d and release kinetics and tissue distribution were measured. PCB153 tiss...

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Bibliographic Details

Published in:	Toxicology Reports
Main Authors:	Farrukh Aqil, Hua Shen, Jeyaprakash Jeyabalan, Xing Xin, Hans-Joachim Lehmler, Gabriele Ludewig, Larry W. Robertson, Ramesh C. Gupta
Format:	Article
Language:	English
Published:	Elsevier 2014-01-01
Subjects:	Polychlorinated biphenyls (PCBs) PCB126 (3,3′,4,4′,5-pentachlorobiphenyl) PCB153 (2,2′,4,4′,5,5′-hexachlorobiphenyl) Polymeric implants DNA adducts 32P-postlabeling CYPs Paraoxonase 1 (PON1)
Online Access:	http://www.sciencedirect.com/science/article/pii/S2214750014000912