Engineering LNPs with polysarcosine lipids for mRNA delivery

Since the approval of the lipid nanoparticles (LNP)-mRNA vaccines against the SARS-CoV-2 virus, there has been an increased interest in the delivery of mRNA through LNPs. However, current LNP formulations contain PEG lipids, which can stimulate the generation of anti-PEG antibodies. The presence of...

Full description

Bibliographic Details
Published in:Bioactive Materials
Main Authors: Diana D. Kang, Xucheng Hou, Leiming Wang, Yonger Xue, Haoyuan Li, Yichen Zhong, Siyu Wang, Binbin Deng, David W. McComb, Yizhou Dong
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-07-01
Subjects:
Lipid nanoparticles
mRNA
Polyethylene glycol (PEG)
Polysarcosine (pSar)
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24000987

Internet

http://www.sciencedirect.com/science/article/pii/S2452199X24000987

Similar Items