Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression.

Pharmacological vitamin C (VC) is a potential natural compound for cancer treatment. However, the mechanism underlying its antitumor effects remains unclear. In this study, we found that pharmacological VC significantly inhibits the mTOR (including mTORC1 and mTORC2) pathway activation and promotes...

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Bibliographic Details

Published in:	PLoS Genetics
Main Authors:	Senlin Qin, Guoyan Wang, Lei Chen, Huijun Geng, Yining Zheng, Chao Xia, Shengru Wu, Junhu Yao, Lu Deng
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2023-02-01
Online Access:	https://doi.org/10.1371/journal.pgen.1010629