The IL‐27/IL‐27R axis is altered in CD4+ and CD8+ T lymphocytes from multiple sclerosis patients

Abstract Objectives Pro‐ and anti‐inflammatory properties have been attributed to interleukin‐27 (IL‐27). Nevertheless, the impact of this cytokine on chronic inflammatory diseases such as multiple sclerosis (MS) remains ill‐defined. We investigated the biology of IL‐27 and its specific receptor IL‐...

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Bibliographic Details

Published in:	Clinical & Translational Immunology
Main Authors:	Marie‐Laure Clénet, Cyril Laurent, Florent Lemaitre, Negar Farzam‐kia, Olivier Tastet, Odile Devergne, Boaz Lahav, Marc Girard, Pierre Duquette, Alexandre Prat, Catherine Larochelle, Nathalie Arbour
Format:	Article
Language:	English
Published:	Wiley 2021-01-01
Subjects:	cytokines IL‐12 neuroimmunology PD‐L1 STAT signalling T cells
Online Access:	https://doi.org/10.1002/cti2.1262