Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways

Cisplatin (CP) is a powerful antineoplastic chemotherapeutic agent with broad-spectrum properties. Acute and cumulative cardiotoxicity are major limiting factors for CP therapy. Various pathogenic pathways have been suggested to CP-induced cardiotoxicity; oxidative damage, ER stress, and programmed...

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Bibliographic Details

Published in:	Toxicology Reports
Main Authors:	Dalia O. Saleh, Dina F. Mansour, Rasha E. Mostafa
Format:	Article
Language:	English
Published:	Elsevier 2020-01-01
Subjects:	Cisplatin Cardiotoxicity ER stress Apoptosis GRP78 Calpain-1
Online Access:	http://www.sciencedirect.com/science/article/pii/S2214750020303887