Tryptophan hydroxylase 2 deficiency alters autism-related behavioural phenotypes in rats

Abstract Serotonin is a crucial neurotransmitter implicated in various physiological processes. Dysregulation of the serotonergic system, particularly in early life, may be associated with neuropsychiatric disorders, including autism spectrum disorder. This study utilises a rat model lacking the cen...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Joanna Golebiowska, Małgorzata Holuj, Natalia Alenina, Michael Bader, Piotr Popik, Agnieszka Nikiforuk
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Subjects:	TPH2-KO Autism USV Rats Serotonin 5-HT
Online Access:	https://doi.org/10.1038/s41598-025-05684-9