Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease

Abstract Mutations or inactivation of parkin, an E3 ubiquitin ligase, are associated with familial form or sporadic Parkinson’s disease (PD), respectively, which manifested with the selective vulnerability of neuronal cells in substantia nigra (SN) and striatum (STR) regions. However, the underlying...

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Bibliographic Details

Published in:	Protein & Cell
Main Authors:	Pingping Song, Shanshan Li, Hao Wu, Ruize Gao, Guanhua Rao, Dongmei Wang, Ziheng Chen, Biao Ma, Hongxia Wang, Nan Sui, Haiteng Deng, Zhuohua Zhang, Tieshan Tang, Zheng Tan, Zehan Han, Tieyuan Lu, Yushan Zhu, Quan Chen
Format:	Article
Language:	English
Published:	Oxford University Press 2016-01-01
Subjects:	parkin sequestosome1/p62 ubiquitin substantia nigra
Online Access:	http://link.springer.com/article/10.1007/s13238-015-0230-9