Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA₂β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes

Type 1 diabetes (T1D) development, in part, is due to ER stress-induced β-cell apoptosis. Activation of the Ca²⁺-independent phospholipase A₂ beta (iPLA₂β) leads to the generation of pro-inflammatory eicosanoids, which contribute t...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Tomader Ali, Xiaoyong Lei, Suzanne E. Barbour, Akio Koizumi, Charles E. Chalfant, Sasanka Ramanadham
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Subjects:	phospholipase A<sub>2</sub> sphingolipids diabetes apoptosis
Online Access:	https://www.mdpi.com/1420-3049/26/21/6361