MC38 colorectal tumor cell lines from two different sources display substantial differences in transcriptome, mutanome and neoantigen expression

IntroductionThe cell line MC38 is a commonly used murine model for colorectal carcinoma. It has a high mutational burden, is sensitive to immune checkpoint immunotherapy and endogenous CD8+ T cell responses against neoantigens have been reported.MethodsHere, we re-sequenced exomes and transcriptomes...

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書誌詳細

出版年:	Frontiers in Immunology
主要な著者:	Barbara Schrörs, Brett J. Hos, Ikra G. Yildiz, Martin Löwer, Franziska Lang, Christoph Holtsträter, Julia Becker, Mathias Vormehr, Ugur Sahin, Ferry Ossendorp, Mustafa Diken
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2023-03-01
主題:	MC38 colorectal carcinoma mutation analysis neoantigens expression profile murine tumor model
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1102282/full