Regulatory T cell therapy for xenotransplantation, what perspectives?

Xenotransplantation has experienced major clinical advancements over the past three years. Yet, despite potent immunosuppressive regimens combining B-cell depleting therapies, T cell activation blockade, complement inhibition, and high-dose steroids, signs of antibody-mediated and cellular rejection...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Raphaël Porret, Erica Lana, Antonio Mancarella, Philippe Guillaume, Manuel Pascual, Raphael P. H. Meier, Jonathan S. Bromberg, Muhammad M. Mohiuddin, Leo H. Buhler, Qizhi Tang, Yannick D. Muller
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	xenotransplantation xenograft tolerance regulatory T cells genetic engineering chimeric antigen receptor cell therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1685682/full