VHL restoration in clear cell renal cell carcinoma improves NK cell infiltration and function

Abstract Background The von Hippel–Lindau (VHL) gene is frequently mutated in clear cell renal cell carcinoma (ccRCC) which results in stabilization of hypoxia-inducible factor (HIF). Despite the well-known immunosuppressive effect of HIF, ccRCC is considered an immunogenic tumor with high lymphocyt...

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Bibliographic Details

Published in:	Cancer Immunology, Immunotherapy
Main Authors:	Le Tong, Apple Hui Min Tay, Weiyingqi Cui, Yaxuan Liu, Yanhong Su, Jiawen Lyu, Leila Hoedemakers, Ying Yang, Monika Ehnman, Barbara Seliger, Par Nordlund, Felix Haglund de Flon, Shi Yong Neo, Andreas Lundqvist
Format:	Article
Language:	English
Published:	Springer 2025-07-01
Subjects:	VHL Clear cell renal cell carcinoma NK cells Infiltration Spheroid Organoid
Online Access:	https://doi.org/10.1007/s00262-025-04132-x