Parent-determined oral montelukast therapy for preschool wheeze with stratification for arachidonate 5-lipoxygenase (ALOX5) promoter genotype: a multicentre, randomised, placebo-controlled trial

Background: The clinical effectiveness of intermittent montelukast for wheeze in young children is unclear. Previous work has been equivocal. Variation in copy numbers of the specificity protein 1-binding motif in the arachidonate 5-lipoxygenase (ALOX5) gene promoter; where the wild type has five co...

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Bibliographic Details

Published in:	Efficacy and Mechanism Evaluation
Main Authors:	Chinedu Nwokoro, Hitesh Pandya, Stephen Turner, Sandra Eldridge, Christopher J Griffiths, Tom Vulliamy, David Price, Marek Sanak, John W Holloway, Rossa Brugha, Lee Koh, Iain Dickson, Clare Rutterford, Jonathan Grigg
Format:	Article
Language:	English
Published:	NIHR Journals Library 2015-11-01
Subjects:	montelukast randomised placebo controlled trial preschool wheeze arachidonate-5-lipoxygenase alox5 leukotriene e4 intermittent treatment
Online Access:	https://doi.org/10.3310/eme02060