Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas.
Organogenesis relies on the spatiotemporal balancing of differentiation and proliferation driven by an expanding pool of progenitor cells. In the mouse pancreas, lineage tracing at the population level has shown that the expanding pancreas progenitors can initially give rise to all endocrine, ductal...
| Published in: | PLoS Biology |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-03-01
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| Online Access: | https://doi.org/10.1371/journal.pbio.1002111 |