A Reaction of <i>N</i>-Substituted Succinimides with Hydroxylamine as a Novel Approach to the Synthesis of Hydroxamic Acids

We describe a novel two-step approach for the synthesis of compounds with a hydroxyl-amide group (hydroxamic acids), which are widely known for their biological activity (histone deacetylase inhibitors, matrix metalloproteinases inhibitors and others). The first stage is the synthesis of <i>N&...

Full description

Bibliographic Details

Published in:	Organics
Main Authors:	Bogdan A. Tretyakov, Svyatoslav Y. Gadomsky, Alexei A. Terentiev
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Subjects:	<i>N</i>-substituted succinimides hydroxylamine hydroxamic acids imide ring opening HDAC inhibitors MMP inhibitors
Online Access:	https://www.mdpi.com/2673-401X/4/2/15