Rare subclonal sequencing of breast cancers indicates putative metastatic driver mutations are predominately acquired after dissemination

Abstract Background Evolutionary models of breast cancer progression differ on the extent to which metastatic potential is pre-encoded within primary tumors. Although metastatic recurrences often harbor putative driver mutations that are not detected in their antecedent primary tumor using standard...

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Bibliographic Details

Published in:	Genome Medicine
Main Authors:	Matthew R. Lawrence-Paul, Tien-chi Pan, Dhruv K. Pant, Natalie N. C. Shih, Yan Chen, George K. Belka, Michael Feldman, Angela DeMichele, Lewis A. Chodosh
Format:	Article
Language:	English
Published:	BMC 2024-02-01
Subjects:	Breast cancer Metastasis Rare subclonal sequencing Ultra-deep sequencing Genomics Metastatic driver mutation
Online Access:	https://doi.org/10.1186/s13073-024-01293-9