Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model

Aromatase Inhibitors (AIs) block estrogen production and improve survival in patients with hormone-receptor-positive breast cancer. However, half of patients develop aromatase-inhibitor-induced arthralgia (AIIA), which is characterized by inflammation of the joints and the surrounding musculoskeleta...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Nicholas A. Young, Jeffrey Hampton, Juhi Sharma, Kyle Jablonski, Courtney DeVries, Anna Bratasz, Lai-Chu Wu, Maryam Lustberg, Raquel Reinbolt, Wael N. Jarjour
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Subjects:	breast cancer hormone-receptor-positive cancer estrogen aromatase inhibitor aromatase-inhibitor-induced arthralgia (AIIA)
Online Access:	https://www.mdpi.com/1424-8247/15/12/1578