Design of Potent and Controllable Anticoagulants Using DNA Aptamers and Nanostructures

The regulation of thrombin activity offers an opportunity to regulate blood clotting because of the central role played by this molecule in the coagulation cascade. Thrombin-binding DNA aptamers have been used to inhibit thrombin activity. In the past, to address the low efficacy reported for these...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Abhijit Rangnekar, Jessica A. Nash, Bethany Goodfred, Yaroslava G. Yingling, Thomas H. LaBean
Format:	Article
Language:	English
Published:	MDPI AG 2016-02-01
Subjects:	thrombin DNA aptamers anticoagulation DNA nanotechnology
Online Access:	http://www.mdpi.com/1420-3049/21/2/202