Matrix Metalloproteinases Inhibition by Doxycycline Rescues Extracellular Matrix Organization and Partly Reverts Myofibroblast Differentiation in Hypermobile Ehlers-Danlos Syndrome Dermal Fibroblasts: A Potential Therapeutic Target?

Hypermobile Ehlers-Danlos syndrome (hEDS) is the most frequent type of EDS and is characterized by generalized joint hypermobility and musculoskeletal manifestations which are associated with chronic pain, and mild skin involvement along with the presence of more than a few comorbid conditions. Desp...

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Bibliographic Details

Published in:	Cells
Main Authors:	Nicola Chiarelli, Nicoletta Zoppi, Marina Venturini, Daniele Capitanio, Cecilia Gelfi, Marco Ritelli, Marina Colombi
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	doxycycline extracellular matrix hypermobile Ehlers-Danlos syndrome matrix metalloproteinases myofibroblasts secretome
Online Access:	https://www.mdpi.com/2073-4409/10/11/3236