The bispecific B7H3xCD3 antibody CC-3 induces T cell immunity against bone and soft tissue sarcomas

Sarcomas are rare and heterogeneous malignancies that are difficult to treat. Approximately 50% of patients diagnosed with sarcoma develop metastatic disease with so far very limited treatment options. The transmembrane protein B7-H3 reportedly is expressed in various malignancies, including differe...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Samuel J. Holzmayer, Kai Liebel, Ilona Hagelstein, Helmut R. Salih, Melanie Märklin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	bispecific antibody B7-H3 CD276 sarcoma T cell engager
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1391954/full