Nucleoside cyclic 3′,5′-phosphorothioates with purine and pyrimidine scaffolds. A chemical minireview

The common nucleobases purine (adenine and guanine) and pyrimidine (cytosine, uracil and thymine) in naturally occurring nucleosides and their 3′,5′-cyclic phosphates are β-bonded to the anomeric carbon (C1′) of d-ribose or its 2′-deoxy congener. These compounds are important second messengers and r...

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Bibliographic Details

Published in:	European Journal of Medicinal Chemistry Reports
Main Author:	Kjell Undheim
Format:	Article
Language:	English
Published:	Elsevier 2022-08-01
Subjects:	Second messengers Cyclic thionucleotides (Rp)-cNMP-thioates cNMPS antagonists cNMPS agonists Stereoselective thiation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772417422000097