Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

<p>Abstract</p> <p>Background</p> <p>Macroautophagy is an evolutionarily conserved mechanism for bulk intracellular degradation of proteins and organelles. Pathological studies have implicated macroautophagy defects in human neurodegenerative disorders of aging includin...

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Bibliographic Details

Published in:	Molecular Neurodegeneration
Main Authors:	Inoue Keiichi, Rispoli Joanne, Kaphzan Hanoch, Klann Eric, Chen Emily I, Kim Jongpil, Komatsu Masaaki, Abeliovich Asa
Format:	Article
Language:	English
Published:	BMC 2012-09-01
Online Access:	http://www.molecularneurodegeneration.com/content/7/1/48