A PIK3CA and NF1 expression-based prognostic signature derived from Mendelian randomization identifies causal immune-regulatory determinants of glioblastoma outcomes

Abstract Objective The causal roles of PIK3CA and NF1 expression in glioblastoma multiforme (GBM) pathogenesis and their immune-regulatory functions remain poorly understood. We developed and validated an expression-based prognostic signature to predict survival and assess immunotherapy-related biom...

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Bibliographic Details
Published in:Discover Oncology
Main Authors: Qinbiao Chen, Min Luo, Wenjing Lin, Linlin Lu, Cheng Zhong, Anmin Liu, Lin Xie
Format: Article
Language:English
Published: Springer 2026-04-01
Subjects:
Mendelian randomization
Glioblastoma multiforme
PIK3CA
NF1
Immunotherapy
Online Access:https://doi.org/10.1007/s12672-026-04658-1

Internet

https://doi.org/10.1007/s12672-026-04658-1

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