Newcastle Disease Virus (NDV) Oncolytic Activity in Human Glioma Tumors Is Dependent on CDKN2A-Type I IFN Gene Cluster Codeletion

Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor in adults with a median overall survival of 15 months. Tumor recurrence and poor prognosis are related to cancer stem cells (CSCs), which drive resistance to therapies. A common characteristic in GBM is <i>CDKN2A</i&...

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Bibliographic Details

Published in:	Cells
Main Authors:	Noemi García-Romero, Irina Palacín-Aliana, Susana Esteban-Rubio, Rodrigo Madurga, Sergio Rius-Rocabert, Josefa Carrión-Navarro, Jesús Presa, Sara Cuadrado-Castano, Pilar Sánchez-Gómez, Adolfo García-Sastre, Estanislao Nistal-Villan, Angel Ayuso-Sacido
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Subjects:	glioblastoma oncolytic virotherapy Newcastle disease virus (NDV) Interferon I
Online Access:	https://www.mdpi.com/2073-4409/9/6/1405