β-Arrestin 2 Promotes Hepatocyte Apoptosis by Inhibiting Akt Pathway in Alcoholic Liver Disease

Alcoholic liver disease (ALD) is a complex process that includes a wide range of hepatic lesions, from steatosis to cirrhosis, and even hepatocellular carcinoma (HCC). Accumulating evidence shows that the cytotoxic effects of ethanol metabolism lead to cell apoptosis and necrosis in ALD. Recently, s...

書誌詳細
出版年:	Frontiers in Pharmacology
主要な著者:	Ying-Yin Sun, Yu-Xin Zhao, Xiao-Feng Li, Cheng Huang, Xiao-Ming Meng, Jun Li
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2018-09-01
主題:	alcoholic liver disease (ALD) β-arrestin 2 (Arrb2) hepatocyte apoptosis Akt
オンライン･アクセス:	https://www.frontiersin.org/article/10.3389/fphar.2018.01031/full

類似資料

β-Arrestin 2 as a Prognostic Indicator and Immunomodulatory Factor in Multiple Myeloma
著者:: Parker Mathews, 等
出版事項: (2025-03-01)

Research progress in the role of β-arrestin 1 in the regulation of inflammatory response
著者:: YI Wenjing, 等
出版事項: (2024-12-01)

Activation of CXCR7 exerts an inhibitory effect on adipogenesis through regulation of β-arrestin2/Wnt and AKT signalling
著者:: Shiyue Sun, 等
出版事項: (2025-12-01)

Loss of β-arrestin2 aggravated condylar cartilage degeneration at the early stage of temporomandibular joint osteoarthritis
著者:: Mengjiao Zhu, 等
出版事項: (2024-06-01)

Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro
著者:: Miao Liu, 等
出版事項: (2025-01-01)

β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
著者:: Jihee Kim, 等
出版事項: (2018-12-01)

Cr(VI)-Induced Autophagy Protects L-02 Hepatocytes from Apoptosis Through the ROS-AKT-mTOR Pathway
著者:: Qi Liang, 等
出版事項: (2018-11-01)

S‐allyl‐l‐cysteine (SAC) protects hepatocytes from alcohol‐induced apoptosis
著者:: Peng Chen, 等
出版事項: (2019-07-01)

High Glucose Attenuates Cardioprotective Effects of Glucagon-Like Peptide-1 Through Induction of Mitochondria Dysfunction via Inhibition of β-Arrestin-Signaling
著者:: Xietian Pan, 等
出版事項: (2021-05-01)

β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression
著者:: Yang Liu, 等
出版事項: (2022-10-01)

GRKs and β-Arrestins: “Gatekeepers” of Mitochondrial Function in the Failing Heart
著者:: Daniela Sorriento, 等
出版事項: (2019-02-01)

MRAP2 Inhibits β-Arrestin-2 Recruitment to the Prokineticin Receptor 2
著者:: Roberta Lattanzi, 等
出版事項: (2024-02-01)

Downregulation of miR‐326 and its host gene β‐arrestin1 induces pro‐survival activity of E2F1 and promotes medulloblastoma growth
著者:: Evelina Miele, 等
出版事項: (2021-02-01)

Control of Cytoskeletal Dynamics by β-Arrestin1/Myosin Vb Signaling Regulates Endosomal Sorting and Scavenging Activity of the Atypical Chemokine Receptor ACKR2
著者:: Alessandro Vacchini, 等
出版事項: (2020-09-01)

Repeated social defeat promotes persistent inflammatory changes in splenic myeloid cells; decreased expression of β-arrestin-2 (ARRB2) and increased expression of interleukin-6 (IL-6)
著者:: Dhaksshaginy Rajalingam, 等
出版事項: (2020-05-01)

G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D<sub>2</sub> Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation
著者:: Marta Sánchez-Soto, 等
出版事項: (2023-10-01)

β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium
著者:: Fuzhou Hua, 等
出版事項: (2023-05-01)

β-Arrestin2 promotes docetaxel resistance of castration-resistant prostate cancer via promoting hnRNP A1-mediated PKM2 alternative splicing
著者:: Yuhao Zhou, 等
出版事項: (2023-11-01)

β-arrestin1-E2F1-ac axis regulates physiological apoptosis and cell cycle exit in cellular models of early postnatal cerebellum
著者:: Luana Abballe, 等
出版事項: (2023-02-01)

α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes
著者:: Ren-Hong Du, 等
出版事項: (2018-09-01)

β-arrestin2 Stimulates Interleukin-17 Production and Expression of CD4+ T Lymphocytes in a Murine Asthma Model
著者:: Yi Liu, 等
出版事項: (2011-09-01)

Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs
著者:: Elisabeth Cassier, 等
出版事項: (2017-02-01)

The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with β-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking
著者:: Gaetan-Nagim Degroot, 等
出版事項: (2022-03-01)

Therapeutic Targets for Treatment of Heart Failure: Focus on GRKs and β-Arrestins Affecting βAR Signaling
著者:: Supachoke Mangmool, 等
出版事項: (2018-11-01)

β-arrestin2 Mediates the Arginine Vasopressin-Induced Expression of IL-1β in Murine Hearts
著者:: Na Yao, 等
出版事項: (2023-01-01)

Metformin protects hepatocytes against oxidative stress-induced apoptosis
著者:: Svetlana Yur'evna Vorotnikova
出版事項: (2015-12-01)

Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway
著者:: Yinquan Fang, 等
出版事項: (2022-01-01)

T‐2 Toxin‐Mediated β‐Arrestin‐1 O‐GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation
著者:: Tushuai Li, 等
出版事項: (2024-02-01)

β-arrestin 2 Is a Prognostic Factor for Survival of Ovarian Cancer Patients Upregulating Cell Proliferation
著者:: Bastian Czogalla, 等
出版事項: (2020-09-01)

Amphetamine pretreatment blunts dopamine-induced D2/D3-receptor occupancy by an arrestin-mediated mechanism: A PET study in internalization compromised mice
著者:: Joseph B. Mandeville, 等
出版事項: (2023-12-01)

Prognostic value of β-Arrestins in combination with glucocorticoid receptor in epithelial ovarian cancer
著者:: Ji-Won Ryu, 等
出版事項: (2023-03-01)

Qifu Yixin Formula Improves Heart Failure by Enhancing β-Arrestin2 Mediated the SUMOylation of SERCA2a
著者:: Wang X, 等
出版事項: (2024-03-01)

Data on the evaluation of the relation between β-arrestin 2 and YAP phosphorylation in patient-derived colon cancer organoids
著者:: Minsuh Kim, 等
出版事項: (2022-10-01)

The PKCι-β-arrestin2 axis disrupts SORLA retrograde trafficking, driving its degradation and amyloid pathology in Alzheimer’s disease
著者:: Hasibur Rehman, 等
出版事項: (2025-06-01)

Investigation of adenosine A1 receptor-mediated β-arrestin 2 recruitment using a split-luciferase assay
著者:: Luisa Saecker, 等
出版事項: (2023-05-01)

β-arrestin1 activates hepatic stellate cells to promote liver fibrosis via activating p38 signaling pathway
著者:: Xia Yanhao, Liu Huiling, Jiang Jie, Wu Bin
出版事項: (2023-01-01)

Regulation of mitochondrial oxidative stress by β-arrestins in cultured human cardiac fibroblasts
著者:: Jennifer L. Philip, 等
出版事項: (2015-12-01)

Expression of β-arrestin1 in oral squamous cell carcinoma and its effect on cell proliferation, migration and invasion
著者:: HAO Xiaohui, 等
出版事項: (2025-07-01)

Therapeutic Potential of Targeting ß-Arrestin
著者:: Richard A. Bond, 等
出版事項: (2019-03-01)

β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
著者:: Carole Daly, 等
出版事項: (2023-10-01)