Oral fibroblasts rescue osteogenic differentiation of mesenchymal stem cells after exposure to Zoledronic acid in a paracrine effect

Background: Medication-related osteonecrosis of the jaw is a serious complication that develops in oncologic patients treated with Zoledronic acid. Although used for over 30 years, the influence of Zoledronic acid on bone has been thoroughly investigated, mainly on osteoclasts. While decreasing oste...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Tal Berg, Ofri Doppelt-Flikshtain, Benjamin R. Coyac, Hadar Zigdon-Giladi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-08-01
Subjects:	osteonecrosis Zoledronic acid fibroblasts mesenchymal stem cells bone
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1172705/full