Variants of unknown significance in fetal heart malformations: distribution and impact on prenatal decision-making

ObjectiveTo investigate the distribution patterns of variants of unknown significance (VUS) in fetuses with heart malformations (CHD) combined with extracardiac abnormalities and their impact on prenatal decision-making.MethodsA retrospective analysis was conducted on the chromosomal microarray anal...

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Bibliographic Details

Published in:	Frontiers in Pediatrics
Main Authors:	Qingsong Wang, Jun Yin, Xiaomeng Zhang, Huimin Ou, Fuyan Li, Yundong Zhang, Caiyu Guo, Weiyi Wan, Yongyu Cao, Tongyong Luo, Xianmin Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	fetal heart malformations variants of unknown significance (VUS) prenatal diagnosis genetic counseling chromosomal microarray analysis (CMA)
Online Access:	https://www.frontiersin.org/articles/10.3389/fped.2025.1605899/full