SLAMF6​ deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint

SLAMF6 is a homotypic receptor of the Ig-superfamily whose exact role in immune modulation has remained elusive. Its constitutive expression on resting and activated T cells precludes it from being a bona fide exhaustion marker. By breeding Pmel-1 mice with SLAMF6 -/- mice, we generated donors for T...

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Bibliographic Details

Published in:	eLife
Main Authors:	Emma Hajaj, Galit Eisenberg, Shiri Klein, Shoshana Frankenburg, Sharon Merims, Inna Ben David, Thomas Eisenhaure, Sarah E Henrickson, Alexandra Chloé Villani, Nir Hacohen, Nathalie Abudi, Rinat Abramovich, Jonathan E Cohen, Tamar Peretz, Andre Veillette, Michal Lotem
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-03-01
Subjects:	checkpoint immunotherapy cancer T cells
Online Access:	https://elifesciences.org/articles/52539