Molecular and histopathological landscape of 131 meningiomas: a retrospective institutional study with insights from cIMPACT-NOW

BackgroundPrognostication in meningiomas has traditionally relied on histopathological grading, which has inherent limitations, including interobserver variability, intratumoral heterogeneity, and inconsistent correlation with clinical behavior. While molecular profiling enhances diagnostic precisio...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Rola H. Ali, Abdulaziz Hassan, Hussain H. Jarkhi, Abdullah Alshawish, Mohamad Almanabri, Obada T. Alhalabi, Ahmad R. Alsaber, Nawal Y. Ali, Ehab Abdelnabi, Eiman M. A. Mohammed, Hiba Jama, Ammar Almarzooq, Zainab Alqallaf, Amir A. Ahmed, Shakir Bahzad, Stefan Hamelmann, Felix Sahm, Maryam Almurshed
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	meningioma molecular sequencing NF2 WHO grade cIMPACT-NOW
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1648953/full