The E2F4/p130 Repressor Complex Cooperates with Oncogenic ΔNp73α To Inhibit Gene Expression in Human Papillomavirus 38 E6/E7-Transformed Keratinocytes and in Cancer Cells

ABSTRACT Tumor suppressor p53 and its related proteins, p63 and p73, can be synthesized as multiple isoforms lacking part of the N- or C-terminal regions. Specifically, high expression of the ΔNp73α isoform is notoriously associated with various human malignancies characterized by poor prognosis. Th...

Full description

Bibliographic Details

Published in:	mSphere
Main Authors:	Valerio Taverniti, Hanna Krynska, Assunta Venuti, Marie-Laure Straub, Cécilia Sirand, Eugenie Lohmann, Maria Carmen Romero-Medina, Stefano Moro, Alexis Robitaille, Luc Negroni, Denise Martinez-Zapien, Murielle Masson, Massimo Tommasino, Katia Zanier
Format:	Article
Language:	English
Published:	American Society for Microbiology 2023-04-01
Subjects:	p53 ΔNp73 isoforms E2F4 p130 protein-protein interactions gene expression
Online Access:	https://journals.asm.org/doi/10.1128/msphere.00056-23