Breast Cancer Phenotype Associated With Li-Fraumeni Syndrome: A Brazilian Cohort Enriched by TP53 p.R337H Carriers

Breast cancer (BC) is the most prevalent malignancy in women with Li-Fraumeni syndrome (LFS). The literature on BC in LFS is limited due to its rarity worldwide. A TP53 founder pathogenic variant (c.1010G>A; p.R337H) is responsible for the higher prevalence of this syndrome among women of Bra...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Renata Lazari Sandoval, Natalia Polidorio, Ana Carolina Rathsam Leite, Mariana Cartaxo, Janina Pontes Pisani, Carla Vanessa Quirino, Loureno Cezana, Natálya Gonçalves Pereira, Allan Andresson Lima Pereira, Benedito Mauro Rossi, Maria Isabel Achatz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-03-01
Subjects:	Li-Fraumeni syndrome TP53 R337H hereditary breast cancer early-onset breast cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.836937/full