Pure argyrophilic grain disease revisited: independent effects on limbic, neocortical, and striato-pallido-nigral degeneration and the development of dementia in a series with a low to moderate Braak stage

Abstract Agyrophilic grains (AGs) are age-related limbic-predominant lesions in which four-repeat tau is selectively accumulated. Because previous methodologically heterogeneous studies have demonstrated inconsistent findings on the relationship between AGs and dementia, whether AGs affect cognitive...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Osamu Yokota, Tomoko Miki, Hanae Nakashima-Yasuda, Hideki Ishizu, Takashi Haraguchi, Chikako Ikeda, Masato Hasegawa, Akinori Miyashita, Takeshi Ikeuchi, Naoto Nishikawa, Shintaro Takenoshita, Koichiro Sudo, Seishi Terada, Manabu Takaki
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Argyrophilic grain Globus pallidus Hippocampal sclerosis Striatum Substantia nigra Subthalamic nucleus
Online Access:	https://doi.org/10.1186/s40478-024-01828-6