Functionalized 3-hydroxy-3-aminoquinoline-oxindole hybrids as promising dual-function anti-plasmodials

Malaria parasites continue to pose a concern. Drug resistance underlines the need for new structural cores that, when combined with existing antimalarial frameworks, can partially re-sensitize drug-resistant parasites to available antimalarial drugs, such as chloroquine (CQ). Herein, we used “covale...

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Bibliographic Details

Published in:	European Journal of Medicinal Chemistry Reports
Main Authors:	Bharvi Sharma, Jenny Legac, Nosipho Cele, Paul Awolade, Philip J. Rosenthal, Parvesh Singh, Vipan Kumar
Format:	Article
Language:	English
Published:	Elsevier 2022-08-01
Subjects:	Oxindoles 4-Aminoquinolines Epoxide-ring opening Chloroquine resistance Hemozoin inhibition PfCRT
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772417422000243