Synthesis, Antiphospholipase A2, Antiprotease, Antibacterial Evaluation and Molecular Docking Analysis of Certain Novel Hydrazones

Some novel hydrazone derivatives 6a–o were synthesized from the key intermediate 4-Chloro-N-(2-hydrazinocarbonyl-phenyl)-benzamide 5 and characterized using IR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. The inhibitory potential against two secretory phospholipase A2 (sPLA2), three p...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Nahed N. E. El-Sayed, Ahmed M. Alafeefy, Mohammed A. Bakht, Vijay H. Masand, Ali Aldalbahi, Nan Chen, Chunhai Fan, Abir Ben Bacha
Format:	Article
Language:	English
Published:	MDPI AG 2016-12-01
Subjects:	benzo[d][1,3]oxazin-4-one aroylhydrazides N-acylhydrazones hydrazones benzylidene hydrazides phospholipases proteases antimicrobial evaluation molecular docking
Online Access:	http://www.mdpi.com/1420-3049/21/12/1664