Genome-wide association and linkage analysis of histidine-rich glycoprotein identifies common variants associated with plasma histidine-rich glycoprotein concentrations

Background: The plasma protein histidine-rich glycoprotein (HRG) interacts with multiple plasma ligands with various roles in coagulation, immunity, and angiogenesis. Through its inhibition of factor XIIa, HRG regulates the contact pathway of blood coagulation. Plasma HRG concentrations are highly h...

Full description

Bibliographic Details

Published in:	Research and Practice in Thrombosis and Haemostasis
Main Authors:	Mary I. Underwood, Ayse Bilge Ozel, Tanay Deepak, Beth McGee, Dave Siemieniak, Rida A. Malik, Cherie Teney, Colin A. Kretz, Jeffery Weitz, Karl C. Desch
Format:	Article
Language:	English
Published:	Elsevier 2025-07-01
Subjects:	complex traits genetic linkage genome-wide association study histidine-rich glycoprotein partial thrompoplastin time thrombophilia
Online Access:	http://www.sciencedirect.com/science/article/pii/S2475037925002791