BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice

Objective: Branched chain amino acid (BCAA) catabolic defects are implicated to be causal determinates of multiple diseases. This work aimed to better understand how enhancing BCAA catabolism affected metabolic homeostasis as well as the mechanisms underlying these improvements. Methods: The rate li...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	Eliza Bollinger, Matthew Peloquin, Jenna Libera, Bina Albuquerque, Evanthia Pashos, Arun Shipstone, Angela Hadjipanayis, Zhongyuan Sun, Gang Xing, Michelle Clasquin, John C. Stansfield, Brendan Tierney, Steven Gernhardt, C. Parker Siddall, Timothy Greizer, Frank J. Geoly, Sarah R. Vargas, Lily C. Gao, George Williams, Mackenzie Marshall, Amy Rosado, Claire Steppan, Kevin J. Filipski, Bei B. Zhang, Russell A. Miller, Rachel J. Roth Flach
Format:	Article
Language:	English
Published:	Elsevier 2022-12-01
Subjects:	BCAA Metabolism Metabolic syndrome NAFLD Diabetes
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877822001806