Distinct Dynamics of Migratory Response to PD-1 and CTLA-4 Blockade Reveals New Mechanistic Insights for Potential T-Cell Reinvigoration following Immune Checkpoint Blockade

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), two clinically relevant targets for the immunotherapy of cancer, are negative regulators of T-cell activation and migration. Optimizing the therapeutic response to CTLA-4 and PD-1 blockade calls for a mo...

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Bibliographic Details

Published in:	Cells
Main Authors:	Fateme Safaeifard, Bahram Goliaei, Amir R. Aref, Mohammad-Hadi Foroughmand-Araabi, Sama Goliaei, Jochen Lorch, Russell W. Jenkins, David A. Barbie, Seyed Peyman Shariatpanahi, Curzio Rüegg
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	organotypic tumor culture immune checkpoint blockade T-cell migration heterogeneous random walks tumor–immune interaction delayed dynamics
Online Access:	https://www.mdpi.com/2073-4409/11/22/3534