Distinct Dynamics of Migratory Response to PD-1 and CTLA-4 Blockade Reveals New Mechanistic Insights for Potential T-Cell Reinvigoration following Immune Checkpoint Blockade

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), two clinically relevant targets for the immunotherapy of cancer, are negative regulators of T-cell activation and migration. Optimizing the therapeutic response to CTLA-4 and PD-1 blockade calls for a mo...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Cells
المؤلفون الرئيسيون:	Fateme Safaeifard, Bahram Goliaei, Amir R. Aref, Mohammad-Hadi Foroughmand-Araabi, Sama Goliaei, Jochen Lorch, Russell W. Jenkins, David A. Barbie, Seyed Peyman Shariatpanahi, Curzio Rüegg
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	MDPI AG 2022-11-01
الموضوعات:	organotypic tumor culture immune checkpoint blockade T-cell migration heterogeneous random walks tumor–immune interaction delayed dynamics
الوصول للمادة أونلاين:	https://www.mdpi.com/2073-4409/11/22/3534