Intracellular Trafficking Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive memory loss. Although AD neuropathological hallmarks are extracellular amyloid plaques and intracellular tau tangles, the best correlate of disease progression is synapse loss. What causes synapse loss...

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Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Authors:	Catarina Perdigão, Mariana A. Barata, Margarida N. Araújo, Farzaneh S. Mirfakhar, Jorge Castanheira, Cláudia Guimas Almeida
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-04-01
Subjects:	late-onset Alzheimer’s disease synapses endocytosis β-amyloid APOE4 PICALM
Online Access:	https://www.frontiersin.org/article/10.3389/fncel.2020.00072/full