Pharmacological inhibition of IRAK4 kinase activity does not prevent cachexia in mice with pancreatic cancer

Abstract Background Inflammation is a hallmark of cachexia; however, effective anti‐inflammatory treatments have not yet been identified. Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a key signalling node linking interleukin‐1 receptor (IL‐1R) and toll‐like receptor (TLR) activation to the...

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Bibliographic Details

Published in:	JCSM Rapid Communications
Main Authors:	Shuxi Qiao, Brianna LaViolette, Brianna LaCarubba Paulhus, Xiangping Li, John Litchfield, Zhenhong Li, John C. Stansfield, Richard L. Gieseck III, Bei B. Zhang, Danna M. Breen
Format:	Article
Language:	English
Published:	Wiley 2023-07-01
Subjects:	Anamorelin Inflammation IRAK4 Pancreatic cancer cachexia
Online Access:	https://doi.org/10.1002/rco2.85