Admixed Populations Improve Power for Variant Discovery and Portability in Genome-Wide Association Studies

Genome-wide association studies (GWAS) are primarily conducted in single-ancestry settings. The low transferability of results has limited our understanding of human genetic architecture across a range of complex traits. In contrast to homogeneous populations, admixed populations provide an opportun...

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書誌詳細

出版年:	Frontiers in Genetics
主要な著者:	Meng Lin, Danny S. Park, Noah A. Zaitlen, Brenna M. Henn, Christopher R. Gignoux
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2021-05-01
主題:	admixture statistical power complex trait genetics polygenic score genetic architecture
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fgene.2021.673167/full