Immunogenicity of chimeric hemagglutinins delivered by an orf virus vector platform against swine influenza virus

Orf virus (ORFV) is a large DNA virus that can harbor and efficiently deliver viral antigens in swine. Here we used ORFV as a vector platform to deliver chimeric hemagglutinins (HA) of Influenza A virus of swine (IAV-S). Vaccine development against IAV-S faces limitations posed by strain-specific im...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Gabriela Mansano do Nascimento, Pablo Sebastian Britto de Oliveira, Salman Latif Butt, Diego G. Diel
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	swine influenza vaccines chimeric HA cross-protection ORFV vectors
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1322879/full