The carbon monoxide prodrug oCOm‐21 increases Ca2+ sensitivity of the cardiac myofilament

Abstract Patients undergoing cardiopulmonary bypass procedures require inotropic support to improve hemodynamic function and cardiac output. Current inotropes such as dobutamine, can promote arrhythmias, prompting a demand for improved inotropes with little effect on intracellular Ca2+ flux. Low‐dos...

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Bibliographic Details

Published in:	Physiological Reports
Main Authors:	Fergus M. Payne, Samantha Nie, Gary M. Diffee, Gerard T. Wilkins, David S. Larsen, Joanne C. Harrison, James C. Baldi, Ivan A. Sammut
Format:	Article
Language:	English
Published:	Wiley 2024-03-01
Subjects:	calcium sensitivity carbon monoxide heme myofilament
Online Access:	https://doi.org/10.14814/phy2.15974