Acquired Glucocorticoid Resistance Due to Homologous Glucocorticoid Receptor Downregulation: A Modern Look at an Age-Old Problem

For over 70 years, the unique anti-inflammatory properties of glucocorticoids (GCs), which mediate their effects via the ligand-activated transcription factor, the glucocorticoid receptor alpha (GRα), have allowed for the use of these steroid hormones in the treatment of various autoimmune and infla...

Full description

Bibliographic Details

Published in:	Cells
Main Authors:	Lee-Maine L. Spies, Nicolette J. D. Verhoog, Ann Louw
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Subjects:	glucocorticoid receptor alpha glucocorticoids glucocorticoid receptor dimerization acquired glucocorticoid resistance ubiquitin-proteasome system
Online Access:	https://www.mdpi.com/2073-4409/10/10/2529