Acquired Glucocorticoid Resistance Due to Homologous Glucocorticoid Receptor Downregulation: A Modern Look at an Age-Old Problem

For over 70 years, the unique anti-inflammatory properties of glucocorticoids (GCs), which mediate their effects via the ligand-activated transcription factor, the glucocorticoid receptor alpha (GRα), have allowed for the use of these steroid hormones in the treatment of various autoimmune and infla...

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Bibliographic Details
Published in:	Cells
Main Authors:	Lee-Maine L. Spies, Nicolette J. D. Verhoog, Ann Louw
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Subjects:	glucocorticoid receptor alpha glucocorticoids glucocorticoid receptor dimerization acquired glucocorticoid resistance ubiquitin-proteasome system
Online Access:	https://www.mdpi.com/2073-4409/10/10/2529

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