Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle release and replenishment in a dosage-dependent manner

Synchronous neurotransmitter release is triggered by Ca2+ binding to the synaptic vesicle protein Synaptotagmin 1, while asynchronous fusion and short-term facilitation is hypothesized to be mediated by plasma membrane-localized Synaptotagmin 7 (SYT7). We generated mutations in Drosophila Syt7 to de...

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Bibliographic Details

Published in:	eLife
Main Authors:	Zhuo Guan, Monica C Quiñones-Frías, Yulia Akbergenova, J Troy Littleton
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-04-01
Subjects:	Synaptotagmin neurotransmitter release exocytosis synapse ready-releasable pool synaptic vesicle
Online Access:	https://elifesciences.org/articles/55443