Reduction of mechanical loading in tendons induces heterotopic ossification and activation of the β-catenin signaling pathway

Background: Tendons are the force transferring tissue that enable joint movement. Excessive mechanical loading is commonly considered as a primary factor causing tendinopathy, however, an increasing body of evidence supports the hypothesis that overloading creates microdamage of collagen fibers resu...

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Bibliographic Details

Published in:	Journal of Orthopaedic Translation
Main Authors:	Tao Wang, Peilin Chen, Lianzhi Chen, Yinghong Zhou, Allan Wang, Qiujian Zheng, Christopher A. Mitchell, Toby Leys, Rocky S. Tuan, Ming H. Zheng
Format:	Article
Language:	English
Published:	Elsevier 2021-07-01
Subjects:	Bioreactor Mechanical loading Heterotopic ossification Tendon-derived stem cell Mechanobiology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2214031X21000206